Mouse Anti-SLC34A2 Recombinant Antibody (TAB-467MZ)
CAT#: TAB-467MZ
This product is a recombinant mouse antibody that recognizes NaPi2b (SCL34A2) (Sodium-dependent phosphate transport protein 2b). The antibody was expressed in mammalian cells with chemically defined culture media and was purified by affinity chromatography.
Tested Data
Gene Expression
SDS-PAGE
Figure 1 Anti-Human SLC34A2 Recombinant Antibody (TAB-467MZ) in SDS-PAGE
SDS-PAGE analysis of TAB-467MZ in non-reduced (Lane 1) and reduced (Lane 2) conditions.
SEC-HPLC
Figure 2 Anti-Human SLC34A2 Recombinant Antibody (TAB-467MZ) in HPLC
HPLC analysis of TAB-467MZ shows the purity is>95%.
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Subcellular Location
Figure 1 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37989/1788_A4_7_cr5971b651a2dbe_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66474/1788_E8_17_cr5971fcb00a73f_selected.jpg
Normal Tissue
Figure 3 High expression in lung
Alveolar cells type Alveolar cells type I I Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37989/141847_A_2_4.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (BEWO, EFO-21, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157765-SLC34A2
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human NaPi2b (SCL34A2) (Sodium-dependent phosphate transport protein 2b)
- Species Reactivity
- Human
- Applications
- FC, Inhib
- Related Disease
- Ovarian cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- SLC34A2; solute carrier family 34 (type II sodium/phosphate cotransporter), member 2; NPTIIb; NAPI-3B; NAPI-IIb; sodium-dependent phosphate transport protein 2B; sodium/phosphate cotransporter 2B; type II sodium-dependent phosphate transporter 3b; solute carrier family 34 (sodium phosphate), member 2
- Gene ID
- 10568
- UniProt ID
- O95436
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Reliable Antibody for Phosphate Studies
As a researcher in cellular metabolism, the Mouse Anti-SLC34A2 Recombinant Antibody has proven vital in my studies on phosphate transport. Its high specificity for the NaPi2b protein ensures accurate detection in various assays, significantly enhancing the reliability of our data. Creative Biolabs' support team has also been exceptional, providing detailed information and efficient service each time.
Valuable for Ovarian Cancer Marker Studies
This antibody has provided invaluable insights into ovarian cancer markers, enhancing our research endeavors significantly. The clarity and consistency it brings to our fluorescence microscopy experiments are remarkable. Our lab highly regards the support and efficient service consistently provided by Creative Biolabs.
Robust Antibody for Flow Cytometry
Our lab utilizes the Mouse Anti-SLC34A2 Recombinant Antibody extensively in flow cytometry, and its performance is commendable. The high specificity results in clear and specific staining patterns, essential for our quantitative analyses of phosphate transport activity in epithelial cells.
Q&As
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What is the primary application of the SLC34A2 antibody in research?
A: The Mouse Anti-SLC34A2 Recombinant Antibody is primarily used in research focused on phosphate transport processes and their role in human health and disease. This antibody targets the Sodium-dependent phosphate transport protein 2b, which is crucial for maintaining phosphate homeostasis in the body. It provides insights into phosphate metabolism pathways, contributing to the understanding of diseases linked to phosphate imbalance.
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How does the target protein SLC34A2 relate to disease?
A: The SLC34A2 gene encodes for a sodium-dependent phosphate transporter crucial in phosphate absorption in the kidneys and intestines. Mutations or dysregulation of this gene can lead to disorders such as hyperphosphatemia or hypophosphatemia, affecting bone health and leading to conditions like ectopic calcification or osteomalacia. This makes SLC34A2 a significant focus in studies related to metabolic bone diseases.
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Which related pathways does the SLC34A2 protein participate in?
A: SLC34A2 is involved in phosphate metabolism pathways, crucial for maintaining the balance of phosphate in the blood and tissues. Disruptions in these pathways can lead to metabolic bone disorders, making them a focal point in research aiming to understand and treat conditions like osteoporosis and chronic kidney disease-related mineral and bone disorder (CKD-MBD).
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-467MZ, RRID: AB_3111958)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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|---|---|---|---|
| TAB-H45 | Human Anti-SLC34A2 Recombinant Antibody (TAB-H45) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Human IgG1, κ |
| CAT | Product Name | Application | Type |
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| TAB-468MZ | Human Anti-SLC34A2 Recombinant Antibody (TAB-468MZ) | FC, Inhib | Humanized antibody |
| TAB-468MZ-S(P) | Human Anti-SLC34A2 Recombinant Antibody; scFv Fragment (TAB-468MZ-S(P)) | SDS-PAGE, IHC, WB | Humanized scFv |
| TAB-468MZ-F(E) | Human Anti-SLC34A2 Recombinant Antibody; Fab Fragment (TAB-468MZ-F(E)) | SDS-PAGE, IHC, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467MZ-S(P) | Mouse Anti-SLC34A2 Recombinant Antibody; scFv Fragment (TAB-467MZ-S(P)) | SDS-PAGE, IHC, WB | Mouse scFv |
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| HPAB-0341LY-S(P) | Human Anti-SLC34A2 Recombinant Antibody; scFv Fragment (HPAB-0341LY-S(P)) | ELISA, Block | Humanized scfv |
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